A taxonomy of seizure dynamotypes

ML Saggio; D Crisp; JM Scott; P Karoly; L Kuhlmann; M Nakatani; T Murai; M Dümpelmann; A Schulze-Bonhage; A Ikeda; M Cook; SV Gliske; J Lin; C Bernard; V Jirsa; WC Stacey

Journal article

A taxonomy of seizure dynamotypes

ML Saggio, D Crisp, JM Scott, P Karoly, L Kuhlmann, M Nakatani, T Murai, M Dümpelmann, A Schulze-Bonhage, A Ikeda, M Cook, SV Gliske, J Lin, C Bernard, V Jirsa, WC Stacey

Elife | eLIFE SCIENCES PUBL LTD | Published : 2020

DOI: 10.7554/eLife.55632

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Abstract

Seizures are a disruption of normal brain activity present across a vast range of species and conditions. We introduce an organizing principle that leads to the first objective Taxonomy of Seizure Dynamics (TSD) based on bifurcation theory. The ‘dynamotype’ of a seizure is the dynamic composition that defines its observable characteristics, including how it starts, evolves and ends. Analyzing over 2000 focal-onset seizures from multiple centers, we find evidence of all 16 dynamotypes predicted in TSD. We demonstrate that patients’ dynamotypes evolve during their lifetime and display complex but systematic variations including hierarchy (certain types are more common), non-bijectivity (a pati..

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University of Melbourne Researchers

Pip Karoly Author

Levin Kuhlmann Author

Mark Cook Author

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Grants

Awarded by European Commission

Funding Acknowledgements

European Union Seventh Framework Programme 211713 Matthias Dumpelmann Andreas Schulze-Bonhage DFG/Cluster of Excellence BrainLinks-BrainTools 1086 Matthias Dumpelmann Andreas Schulze-Bonhage Ministry of Education, Culture, Sports, Science and Technology 15H05871 Tomohiko Murai Akio Ikeda Ministry of Education, Culture, Sports, Science and Technology 19H03574 Tomohiko Murai Akio Ikeda National Health and Medical Research Council GNT1183119 Mark Cook Levin Kuhlmann Ligue Francaise contre l'Epilepsie Maria Luisa Saggio Horizon 2020 Framework Programme 785907 Viktor Jirsa Horizon 2020 Framework Programme 945539 Viktor Jirsa Horizon 2020 m-Gate project Marie Sklodowska-Curie grant agreement no. 765549 Mitsuyoshi Nakatani Fondation pour la Recherche Medicale DIC 20161236442 Christophe Bernard Viktor Jirsa SATT Sud Est The Virtual Brain Christophe Bernard Viktor Jirsa Agence Nationale de la Recherche EPINOV Viktor Jirsa National Institutes of Health K01-ES026839 Stephen V Gliske National Institutes of Health K08-NS069783 Stephen V Gliske William C Stacey National Institutes of Health R01-NS094399 Dakota Crisp Jared M Scott Stephen V Gliske Jack Lin William C Stacey Michigan Medicine Robbins Family Research Fund Dakota Crisp William C Stacey Michigan Medicine Lucas Family Research Fund Dakota Crisp William C Stacey